The authors noted that it's possible that redness gets overlooked or may not be as obvious on dark skin. Autoimmune and autoinflammatory conditions after COVID-19 vaccination. mRNA (Nucleoside-modified mRNA encoding the viral spike (S) glycoprotein of SARS-CoV-2; Lipids. Nick Blackmer is a librarian, fact-checker, and researcher with more than 20 years experience in consumer-oriented health and wellness content. Baden LR, El Sahly HM, Essink B, et al.. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. Unable to load your collection due to an error, Unable to load your delegates due to an error. Do not puncture the vial more than 20 times. Can People With MS Get the COVID-19 Vaccine? 2020 Dec 1;16(12):2891-2904. doi: 10.1080/21645515.2020.1788310. It will also have the potential to develop vaccines targeting a range of. There was also someone whose reaction was mistaken for cellulitis and treated with antibiotics noted in the JAMA Dermatology report of patients at Yale New Haven Hospital. Opens in a new tab or window, Share on LinkedIn. Information about both vaccine doses was available for 180 patients, 29 of whom had skin reactions after both doses. It is recommended to get the second dose 28 days after the first dose to complete the vaccination course. News stories, speeches, letters and notices. GC led the study and wrote the report. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. The vaccine was co-developed by Moderna, Inc., a biotechnology company based in Cambridge, Massachusetts, and the National Institute of Allergy and Infectious Diseases (NIAID), part of the National . Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. You can change your cookie settings at any time. Opens in a new tab or window, Visit us on Facebook. If you do develop one, don't panic. If you are concerned about a side-effect it can be reported directly via the Coronavirus Yellow Card reporting site or search for MHRA Yellow Card in the Google Play or Apple App Store and include the vaccine brand and batch/Lot number if available. The JAMA Dermatology report included a broader age range of 25 to 89, with the majority of people also identified as White and female. People aged 16 and over, and some children aged 12 to 15, can also get a booster dose. Delayed urticaria appeared to occur more often after vaccination with the Pfizer vaccine (26% and 18%), as did morbilliform rash (18% and 7.5%) and flares of existing dermatologic conditions (24% and 7.5%). The study is based on data from the CDC and the FDA. This leaflet was last revised December 2022. This means that there is more evidence to come about this vaccine. Dont worry we wont send you spam or share your email address with anyone. Is the COVID Vaccine Safe for People With Lung Cancer? Polyethylene glycol (PEG) 2000 dimyristoyl glycerol (DMG) 1,2-distearoyl-sn-glycero-3-phosphocholine; Cholesterol; SM-102 (Proprietary to Moderna) Salts. An additional overfill is included in each vial to ensure that 10 doses of 0.5 mL or a maximum of 20 National Library of Medicine In: Mandell GL, Bennett JE, Dolin R. (eds) Principles and Practice of Infectious Diseases. BMC Infect Dis. Please enable it to take advantage of the complete set of features! There was also one person who had a delayed reaction after the second dose only. 2021;384:403-416. Spikevax vials are multidose. "I think this is particularly interesting because it shows that the body is mounting an immune response to the vaccine, just as it does after infection with the virus," said Freeman. Erythematous, pruritic, painful, indurated plaque in a 33-year-old woman (patient 3) 7days after first dose of vaccine. Careers. Moderna COVID-19 6 5 : . Source Reference: McMahon DE, et al "Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases" J Am Acad Dermatol 2021; DOI: 10.1016/j.jaad.2021.03.092. Trials. an abnormal one at injection site), Injection site paraesthesia (abnormal skin sensations at injection site), Injection site pruritus (severe itching at injection site), Injection site urticaria (rash of round, red welts on the skin at injection site), Injection site vesicles (fluid- or air-filled cavity or sac at injection site), Ischaemic stroke (stroke; caused by an interruption in the flow of blood to the brain), Joint range of motion decreased (disease of joint movement), Leukocytosis (increased white blood cells), Local reaction (reaction of any substance at the site of use), Lung consolidation (a condition whereby the lung tissues solidify because of the accumulation of solid and liquid material in the air spaces), Lung infiltration (a substance that normally includes fluid, inflammatory exudates or cells that fill a region of lung), Lymphadenitis (inflammation or enlargement of a lymph node), Lymph follicular hypertrophy (an increase in the size of the lymph node follicles), Lymphoedema (localized fluid retention and tissue swelling), Malaise (a feeling of general discomfort or uneasiness), Maternal exposure before pregnancy (use of substance before pregnancy), Maternal exposure during pregnancy (use of substance during pregnancy), Mechanical urticaria (urticaria is triggered by mechanical shearing forces e.g. "People were confusing these delayed reactions with cellulitis or skin infection, and so we were able to provide reassurance," said Freeman. should be vaccinated as appropriate. Epub 2022 Jun 21. We declare no competing interests. New case reports and updated literature review. Would you like email updates of new search results? Delayed large local reactions occurred after 15% of first doses and after 18% of second doses. 2021:384(5). eCollection 2022 Sep. Rodrguez Y, Rojas M, Beltrn S, Polo F, Camacho-Domnguez L, Morales SD, Gershwin ME, Anaya JM. feeling faint or light-headed changes in your heartbeat shortness of breath wheezing swelling of your lips, face, tongue or throat hives or rash nausea or vomiting stomach pain Talk to your doctor. Moderna said people without insurance will be able to get its COVID vaccine at no cost after the U.S. government bows out. Hosseinzadeh A, Ebrahimi K, Shahriarirad R, Dalfardi F. Clin Case Rep. 2022 Dec 15;10(12):e6317. 1 Injection site pain, redness, or swelling Both the Moderna vaccine and the Pfizer vaccine may produce a reaction around the area on your arm where you got your shot. Madrid 28002. We saw the reactions on different skin tones but did not see any reaction on dark skin," Saff says. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. V-safe is a new voluntary smartphone-based tool that uses . The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). According to the report, 472 people died after receiving a Moderna vaccine, while 489 died after receiving a Pfizer vaccine. According to the FDA,. To help us improve GOV.UK, wed like to know more about your visit today. The active substance in Spikevax is mRNA encoding the SARS-CoV-2 Spike protein. There were 2 SAEs among 2 participants in the placebo group (affective disorder and COVID-19). Overview. Thrombotic thrombocytopenia after ChAdOx1 nCoV-19 vaccination. Vaccines against SARS-CoV-2 represent a pivotal and effective countermeasure to contain the COVID-19 pandemic. Read all of this leaflet carefully before you receive this vaccine because it contains important information for you. Spikevax may affect the way other medicines work, and other medicines may affect how Spikevax works. This publication is licensed under the terms of the Open Government Licence v3.0 except where otherwise stated. News stories, speeches, letters and notices, Reports, analysis and official statistics, Data, Freedom of Information releases and corporate reports. A new study finds some of them, including COVID toes, a measleslike rash and shingles also can be rare, and thankfully brief, side . Subcutaneous injections can lead to localised cellulitis, granuloma formation and abscess. Washrawirul C, Triwatcharikorn J, Phannajit J, Ullman M, Susantitaphong P, Rerknimitr P. J Eur Acad Dermatol Venereol. The Centers for Disease Control and Prevention (CDC) now recommends that all individuals 5 years old who have completed a primary COVID-19 vaccine series (including those who already received booster doses with monovalent vaccines) receive a single booster dose with one of the bivalent vaccines at least two months after the last vaccine dose; bivalent booster recommendations for children . The registry showed a total of 10 flares, five after a first dose of Moderna vaccine, one after an initial dose of Pfizer vaccine, and four after the second Pfizer dose. This vaccine has been given conditional approval. If you have any further questions on the use of this vaccine, ask your doctor, pharmacist or nurse. Swaetz M. Cellulitis and subcutaneous tissue infections. Published 2021. While it may cause you discomfort, it's likely not serious and should resolve on its own in a short time (about two to 11 days, according to the NEJM study). The https:// ensures that you are connecting to the Symptoms may include: hives swelling wheezing or trouble breathing Some people get a rash at the injection. 2021 Sep;20(9):2684-2690. doi: 10.1111/jocd.14312. 2021 Nov 13;114(9):659-660. doi: 10.1093/qjmed/hcab161. It appears as a red, warm, pruritic, indurated, or swollen area in the vicinity of the vaccine site. headache, muscle pain, joint pain. by Ned Tijdschr Geneeskd. You may also be given an option to enroll in v-safe. Epub 2022 Aug 24. When a COVID vaccine is injected into your arm muscle, your body starts building SARS-CoV-2 virus spike proteins. Moderna's COVID-19 vaccines have been a massive cash windfall for . Gastrointestinal symptoms including nausea, vomiting, abdominal pain, and diarrhea. To relieve symptoms, experts recommend taking an antihistamine and using a topical steroids for any itchiness, swelling, and redness. Read our, Expect Mild Side Effects From COVID-19 Vaccines, CDC Advisory Group Says, Reactions Could Be More Common Than Statistics Show, An Overview of the Moderna COVID-19 Vaccine, Psoriatic Arthritis and COVID Vaccines: What You Should Know. doi: 10.1002/ccr3.6317. However, the actual percentage is likely higher. "There may be genetic factors at playwe know that genetics can be a risk for certain T-cell reactions to drugsbut otherwise, we dont fully understand why someone has a response while another does [not] for most drugs and vaccines.". Ankylosing Spondylitis and the COVID Vaccine: Is It Safe? "Side effects that have been reported with the Moderna COVID-19 Vaccine include: Injection site reactions: pain, tenderness and swelling of the lymph nodes in the same arm of the injection, swelling (hardness), and redness. Monts, France 37260, Moderna Biotech Spain S.L. Subcuta-neous injection can happen inadvertently (figure 1), affecting efficacy of vaccination and potentiate local adverse events. The site is secure. A large amount of information from pregnant women vaccinated with Spikevax during the second and third trimester have not shown negative effects on the pregnancy or the newborn baby. Cellulitis staphylococcal is reported only by a few people who get Moderna COVID Vaccine. A booster dose (0.25 mL, 50 micrograms) of Spikevax may be given at least 3 months after a primary A few patients developed pernio/chilblains, better known as "COVID toes." The site is secure. Epub 2022 Jul 4. Moderna has 24 mRNA vaccines and therapeutics under investigation, and 14 have begun clinical studies, according to the. We also use cookies set by other sites to help us deliver content from their services. Spikevax will be given to you as two 0.5 mL injections. If you get the Moderna COVID-19 vaccine, there is a small chance that you could develop a skin reaction. Prepare and administer the vaccine following manufacturer's guidance which is outlined in CDC's Preparation and Administration summary below. doi: 10.1002/ccr3.6314. Perspective of patients with autoimmune diseases on COVID-19 vaccination. Verywell Health's content is for informational and educational purposes only. T cells are a part of the immune system that directly attacks threats and help protect you from infections. JAMA Dermatol. Vaccine Types. extensive swelling of the vaccinated limb, heavy menstrual bleeding (most cases appeared to be non-serious and temporary in nature). Eczema and the COVID-19 Vaccine: Is it Safe? The study said they were associated with younger patients, lasted for an average of 12.7 days, appeared later in the course of COVID-19 and were associated with less severe cases of the disease. not provide full immunity to COVID-19 in people who are immunocompromised, and you should Common Moderna COVID-19 Vaccine side effects may include: fever, chills; redness or a hardness and swelling where the shot was given; swelling or tenderness under your arm; nausea, vomiting; feeling tired; or. As a physician, I knew the possible side-effects of the new Moderna COVID-19 vaccine: fever, muscle pain, local redness, local swelling and axillary (arm pit) lymph nodes, but those were. 20052022 MedPage Today, LLC, a Ziff Davis company. "Ice can also be helpful for the swelling and pain at the site.". March 2021. doi:10.1056/NEJMoa2035389, Johnston MS, Galan A, Watsky KL, Little AJ. Moderna COVID-19 Vaccine is a monovalent COVID-19 vaccine that is authorized for emergency use to prevent COVID-19 as a: Two-dose primary series for individuals 6 months of age and. Audio will be available later today. The .gov means its official. To update your cookie settings, please visit the, https://doi.org/10.1016/S2665-9913(21)00309-X, Cutaneous vasculitis following COVID-19 vaccination, https://www.governo.it/it/cscovid19/report-vaccini, View Large 2022 Sep 27;9(10):ofac499. Who can get a COVID-19 vaccine Everyone aged 5 (on or before 31 August 2022) and over can get a 1st and 2nd dose of the COVID-19 vaccine. Chest imaging (ie, x-ray or CT), urinalysis, and a search for stool blood were also negative. 2022 Jun 29;9(3):212-243. doi: 10.3390/dermatopathology9030027. The COVID-19 vaccine has shown to have high efficacy if given correctly intramuscularly. eczema, diabetes, and cellulitis were 10-20% more likely. Opens in a new tab or window, Visit us on YouTube. From April, another bivalent COVID-19 vaccine will be available after the Australian Technical Advisory Group on Immunisation (ATAGI) approved Moderna's second Omicron-specific vaccine. He joined MedPage Today in 2007. Not uncommonly, skin reactions were accompanied by systemic effects, including fatigue, myalgia, headache, fever, arthralgia, nausea, and chills. Spikevax can be given during breastfeeding. ), unusual feeling in the skin, such as tingling or a crawling feeling (paraesthesia), Inflammation of the heart muscle (myocarditis) or inflammation of the lining outside the heart (pericarditis) which can result in breathlessness, palpitations or chest pain, Severe allergic reactions with breathing difficulties (anaphylaxis), Reaction of increased sensitivity or intolerance by the immune system (hypersensitivity). The registry added to a recent report of zoster flare as a skin reaction associated with COVID vaccination. Interleukin 1alpha: a comprehensive review on the role of IL-1alpha in the pathogenesis and treatment of autoimmune and inflammatory diseases. COVID arm; COVID-19 vaccine; T-cell mediated; delayed hypersensitivity reactions; mRNA vaccines; post-vaccination reactions; skin and soft tissue infection; treatment of COVID arm; vaccine allergy; vaccine safety. The mRNA is embedded in SM-102 lipid nanoparticles. a skin reaction that causes red spots or patches on the skin that may look like a target or bulls eye with a dark red centre surrounded by paler red rings (erythema multiforme). General side effects: fatigue, headache, muscle pain, joint pain, chills, nausea and vomiting, and fever. J Cosmet Dermatol. The expiry date refers to the last day of that month. If youre finding the symptoms hard to bear, Saff recommends several basic home remedies and over-the-counter (OTC) medications for relief. N Engl J Med. Spikevax is also available as two adapted . This site needs JavaScript to work properly. In addition, you can report side effects to ModernaTX, Inc. at 1-866-663-3762. There are no data to assess the concomitant administration of Spikevax with other vaccines. If side effects such as pain and/or fever are troublesome, they can be treated by medicines for pain and fever such as paracetamol. Although we cannot exclude the possibility that the onset of vasculitis following vaccination was coincidental, striking similarities between these three patients argue for pathogenic causality. 2021 Apr 13;22(1):276. doi: 10.1186/s13063-021-05180-1. Moderna COVID-19 vaccine generates long-lasting immune memory At a Glance People who received low doses of the Moderna COVID-19 vaccine had strong immune memories of the virus six months after being fully vaccinated. The doses are administered 28 days apart, and the vaccine trains the immune system to fight against future. A review of 414 skin reactions associated with the Moderna and Pfizer vaccines showed a variety of rashes, eruptions, and injection-site inflammation. This site needs JavaScript to work properly. -. Moderna's coronavirus vaccine may cause alarming delayed side effects from its first dose among a portion of recipients. 2023 eHealthMe.com. For the most recent updates on COVID-19, visit our coronavirus news page. COVID-19 vaccine efficacy and effectiveness-the elephant (not) in the room. Cardiovascular symptoms, including faintness, syncope, altered mental status, palpitations, and hypotension. QJM. They were about 2.6 times as likely . Specifically, vasculitis developed in healthy individuals with no personal or family history of autoimmunity; clinical manifestations were similar and characterised by widespread cutaneous vasculitis with no visceral involvement; and there was a temporal association between vaccination and the development of clinical manifestations, with no other intercurrent inciting events. While immediate reactions to the COVID-19 vaccines are common, these reports raised awareness that delayed skin reactions can also show up days to weeks after a Moderna shot. Ten (10) doses (of 0.5mL each) or a maximum of twenty (20) doses (of 0.25mL each) can be withdrawn from each multidose vial. The material on this site is for informational purposes only, and is not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. If you are immunocompromised, you may receive a third dose of Spikevax. Caffarelli C, Liotti L, Bianchi A, Bottau P, Caimmi S, Crisafulli G, Franceschini F, Paglialunga C, Saretta F, Mori F. Pediatr Allergy Immunol. The swelling typically goes down in about two to 11 days. By contrast, 244 (0.8%) developed a delayed skin reactiondefined as a skin reaction that appears eight or more days laterafter getting their first dose, and 68 (0.2%) developed a delayed skin reaction after getting their second dose. Your doctor, pharmacist or nurse will inject the vaccine into a muscle (intramuscular injection) in your COVID-19 vaccines: comparison of biological, pharmacological characteristics and adverse effects of Pfizer/BioNTech and Moderna Vaccines. lead to localised cellulitis, granuloma formation and abscess. Those carrying cross-reactive T cells from earlier exposure to other coronaviruses had greater immune responses after vaccination. A few cases of capillary leak syndrome flare-ups (causing fluid leakage from small blood vessels (capillaries) resulting in rapid swelling of the arms and legs, sudden weight gain and feeling faint, low blood pressure) have been reported following vaccination with Spikevax. Bookshelf Investigators identified no safety concerns and no evidence of vaccine-associated enhanced respiratory disease (VAERD). 2022 Sep;21(9):3636-3650. doi: 10.1111/jocd.15261. Where we have identified any third party copyright information you will need to obtain permission from the copyright holders concerned. The Moderna COVID-19 Vaccine should be transported in the frozen state. https://www.hhs.gov/immunization/basics/types/index.html. The registry data included a total of eight cases of pernio/chilblains, three each after the first dose of both vaccines and two after the second Pfizer vaccine dose. We study millions of patients and 5,000 more each day. While the coronavirus 2019 (COVID-19) vaccine is currently being rolled out, some vaccine recipients are experiencing adverse effects (AEs), one of which includes a delayed large local reaction. 2012;4:1011-1033. Moderna's COVID-19 vaccine, also known as mRNA-1273, is a two-dose vaccine. Kimberly Blumenthal, MD, lead author of the NEJM paper and co-director of the clinical epidemiology program in the division of rheumatology, allergy, and immunology at Massachusetts General Hospital, tells Verywell that the skin reactions can be as large as almost 20 centimeters, taking up most of the upper arm. However, the areas can also be much smaller. If you have itching, swelling, or tenderness at the injection site in the days after getting either dose of the vaccine, don't panic. The phase IV clinical study analyzes which people get Moderna COVID Vaccine and have Cellulitis staphylococcal. All rights reserved. DOI: https://doi.org/10.1016/S2665-9913(21)00309-X. Spikevax is a vaccine used to prevent COVID-19 caused by SARS-CoV-2. This publication is available at https://www.gov.uk/government/publications/regulatory-approval-of-covid-19-vaccine-moderna/information-for-uk-recipients-on-covid-19-vaccine-moderna, Spikevax dispersion for injection The company has forecast Covid vaccine sales of $5 billion for . Thromboses and COVID-19: reducing inflammation in addition to thromboprophylaxis. Spikevax will be given to you as two 0.25 mL injections. The Centers for Disease Control and Prevention lists injection . Typical side effects include pain at the injection site, fever, fatigue, headache, muscle pain, chills and diarrhoea. Reply. The swelling typically goes down in about two to 11 days. . Another report published in the Journal of the American Medical Association (JAMA) Dermatology on May 12, 2021 described 15 cases of skin reactionssometimes called "COVID arm"that occurred within two to 12 days after a first dose of the Moderna vaccine. The phase IV clinical study analyzes which people get Moderna COVID Vaccine and have Cellulitis staphylococcal. Getting COVID-19 can cause all manner of odd skin reactions. it damages the myelin sheath), Muscle contractions involuntary (uncontrolled muscle contraction), Muscle strain (an injury to a muscle in which the muscle fibres tear), Musculoskeletal chest pain (pain in chest muscle or nerve or bones), Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves), Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves), Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves), Myocarditis (inflammation of heart muscle myocardium), Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels), Nasopharyngitis (inflammation of the nasopharynx), Nausea (feeling of having an urge to vomit), Nervous system disorder (a general class of medical conditions affecting the nervous system), Neurological symptom (symptoms of nervous system disease), Neuropathy peripheral (surface nerve damage), Neutrophil count increased (excess than normal number of neutrophil a type of blood cell), Numbness and tingling (unusual prickling sensations), Ocular discomfort (a generic expression when there is lack of ease in/about the eyes), Ocular hyperaemia (an abnormally large amount of blood in eye), Oral discomfort (pain or irritation in mouth), Oropharyngeal discomfort (pain or irritation of oropharynx), Osteoarthritis (a joint disease caused by cartilage loss in a joint), Paleness (unusual lightness of skin colour), Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect), Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect), Parosmia (distortion of the sense of smell, as in smelling odours that are not present), Periarthritis (inflammation of the external coats of an artery and of the tissues around the artery), Pericardial effusion (fluid around the heart), Pericarditis (inflammation of the pericardium), Pharyngeal hypoaesthesia (pharyngeal -abnormally decreased sensitivity), Photophobia (extreme sensitivity to light), Photopsia (presence of perceived flashes of light), Pneumonia bacterial (pneumonia associated with bacterial infection), Pollakiuria (abnormally frequent passage of relatively small quantities or urine), Polymyalgia rheumatica (pain in many muscles), Postmenopausal haemorrhage (post-menopausal bleeding), Psoriasis (immune-mediated disease that affects the skin), Pulmonary congestion (congestion in the lungs), Pulmonary embolism (blockage of the main artery of the lung), Pulmonary oedema (fluid accumulation in the lungs), Pulmonary thrombosis (scarring in the lungs), Purpura (purplish discoloration of the skin), Rash maculo-papular (red area on the skin that is covered with small confluent bumps), Rash vesicular (rash with a small bubble), Red blood cell sedimentation rate increased, Renal impairment (severely reduced kidney function), Respiratory acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease), Respiratory disorder (respiratory disease), Respiratory distress (difficulty in breathing), Respiratory rate increased (excess breathing rate/min), Respiratory syncytial virus test negative, Respiratory tract congestion (blockage on respiratory system), Restless leg syndrome (a powerful urge to move your legs), Retching (strong involuntary effort to vomit), Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down), Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints), Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder), Salivary hypersecretion (excess saliva secretion), Scab (a hard coating on the skin formed during the wound healing), Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve), Scleroma (a hardened patch of tissue in the skin or mucous membranes), Seizure like phenomena (a variety of medical conditions may produce sudden episodes which have some similarities to epileptic seizures), Seizures (abnormal excessive or synchronous neuronal activity in the brain), Sepsis (a severe blood infection that can lead to organ failure and death), Septic shock (shock due to blood infection), Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin), Sinus headache (headache caused by sinus infections), Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node), Skin blushing/flushing (a sudden reddening of the face, neck), Skin discoloration - bluish (bluish colour of skin), Skin exfoliation (removal of the oldest dead skin cells), Skin induration (an abnormally hard spot or area on the skin), Speech impairment (adult) (inability to speak (adult)), Stomatitis (inflammation of mucous membrane of mouth), Stroke (sudden death of a portion of the brain cells due to a lack of oxygen), Supraventricular extrasystoles (premature electrical impulse in the heart, generated above the level of the ventricle), Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue), Tenderness (pain or discomfort when an affected area is touched), Tendonitis (a condition that causes pain and swelling of tendons), The flu (the flu is caused by an influenza virus), Thrombocytopenia (decrease of platelets in blood), Thrombosis (formation of a blood clot inside a blood vessel), Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)), Tremor (trembling or shaking movements in one or more parts of your body), Trigeminal neuralgia (a painful condition of the nerve responsible for most facial sensation), Tunnel vision (the loss of peripheral vision with retention of central vision), Type iv hypersensitivity reaction (delayed type hypersensitivity as the reaction takes two to three days to develop), Urinary incontinence (inability to control the flow of urine and involuntary urination), Urinary retention (the inability to completely or partially empty the bladder), Urticaria (rash of round, red welts on the skin that itch intensely), Urticaria chronic (long lasting rash of round, red welts on the skin that itch intensely), Vaccination site erythema (redness around vaccination site), Vaccination site lymphadenopathy (abnormal enlargement of the lymph nodes- vaccination site), Vaccination site pruritus (severe itching of the skin at vaccination site), Vasculitis (inflammation of a blood vessel or blood vessels), Ventricular extrasystoles (premature cardiac contraction), Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart), Vitreous floaters (spots before the eyes), Wheezing (a high-pitched whistling sound made while you breath), Simvastatin and Anaemia Of Chronic Disease, Cytarabine and Therapeutic Agent Toxicity, Lansoprazole and Injection Site Urticaria, Staphylococcus Test Positive: 1 person, 50.00%, Staphylococcal Infection (an infection with staphylococcus bacteria): 1 person, 50.00%, Periorbital Cellulitis (inflammation and infection of the eyelid and the skin surrounding the eye): 1 person, 50.00%, Muscle Aches (muscle pain): 1 person, 50.00%, Culture Wound Positive: 1 person, 50.00%, Cellulitis (infection under the skin): 1 person, 50.00%.